作者：黄晓丹,傅英,陈禧翎,罗建明

【摘要】  目的 建立用HPLC法测定清开灵胶囊中栀子苷含量的方法。方法 采用安捷伦Agilent 1100型高效液相色谱仪,Gracesmart C18色谱柱,检测波长238 nm,以乙腈-水(15∶85)为流动相,流速为1.0 mL/min。结果 线性范围0.060 4～0.302 0 g(r＝0.999 8)；平均回收率为98.73%(n＝10),RSD＝1.61%。结论 本方法准确可靠,可用于清开灵胶囊中栀子苷含量的测定。

【关键词】  高效液相色谱法；清开灵胶囊；栀子苷；含量测定

    Abstract：Objective To establish a HPLC method for determination of geniposide content in Qingkailing Capsule. Methods HPLC with Gracesmart C18 was used and detection wavelength was 238 nm with acetonitrile-water (15∶85) as mobile phase. The flow rate was 1.0 mL/min. Results The standard curve was linear over the range of 0.060 4～0.302 0 μg (r＝0.999 8). The average recovery was 98.73%, and RSD was 1.61%. Conclusion This method is reliable, accurate and suitable for the determination of geniposide in Qingkailing Capsu

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