作者：马国平,刘志辉,钱芳,陆超

【摘要】  目的 优选宣肺止咳合剂的提取工艺。方法 以盐酸麻黄碱含量、正丁醇萃取得率和水提浸膏得率为指标,采用正交试验法,考察水提的工艺条件：加水量、提取时间、提取次数。结果 最佳提取工艺为：加8倍量水,煎煮2次,每次60 min。结论 本研究试验结果可靠,最佳工艺条件适合批量生产。

【关键词】  宣肺止咳合剂；盐酸麻黄碱；正交试验；提取工艺

    Abstract：Objective To optimize the extraction process of Xuanfei Zhike Mixture. Methods The preparation process was investigated by L9(34) orthogonal design with content of ephedrine hydrochloride, the extraction rate of n-butanol and total extraction as indexes. The main factors influencing the extraction efficiency such as the amount of added water, the time of extraction and times of boiling were investigated. Results The optimum technical condition was as follows：8 times amount of water, extract 2 times and 60 min for each time. Conclusion The result is reliable. It can be used for mass production.

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