| 黄芩素体内抗甲型流感病毒作用的研究 |
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作者：吴修华,刘妮,杨丽,沈海容
【摘要】 【目的】观察黄芩素的体内抗甲型流感病毒作用。【方法】选用NIH小鼠，随机分为正常对照组，模型组，病毒唑组（剂量为007g·kg-1·d-1）,黄芩素高、中、低剂量组（剂量分别为100、10、1μg·kg-1·d-1）;采用甲1型流感病毒肺适应株FM1滴鼻感染复制模型后，检测各组肺指数、肺指数抑制率、存活率及死亡保护率，并行肺组织病理检查。【结果】模型组肺指数和存活率显著性降低，与正常对照组比较差异有显著性意义（P＜001），肺组织出现明显炎性突变；黄芩素高剂量组可显著性升高肺指数和存活率，与模型组比较差异有显著性意义（P＜005）,并可明显改善模型小鼠的肺组织炎性突变，作用与阳性对照药病毒唑相仿。【结论】黄芩素具有一定的体内抗甲型流感病毒作用。
【关键词】 黄芩素/药理学；病毒性肺炎/中药疗法；流感病毒，甲型；肺组织/病理学；疾病模型，动物；小鼠
Abstract: ObjectiveTo investigate the antivirus effect of baicalein on influenza A virus in vivo．MethodsNIH mice were randomized into the normal control group，model group，virazole group (at the dose of 007g·kg-1·d-1)，high，middle and lowdose baicalein groups (100，10 and 1 μg·kg-1·d-1 respectively). Mice infected models were induced by intranasal drip of influenza A virus strain FM1. The lung index，inhibitory rate of lung index，survival rate and death prevention rate as well as the pathological changes of lungs were observed.ResultsCompared with the normal control group，the lung index and survival rate were decreased (P＜001)，and inflammatory changes were shown in the lungs；the lung index and survival rate were markedly increased in highdose baicalein group(P＜005 compared with the model group)，and the lung inflammatory changes were relieved，the above effects being similar to those of virazole.Conclusion Baicalein exerts certain invivo antivirus effect on influenza A virus．
Key words:BAICALEIN/pharmacology；VIRAL PNEUMONIA/TCD therapy;INFLUENZA A VIRUS;LUNG/pathology；DISEASE MODELS，ANIMAL；MICE
黄芩是常用中药，具有清热燥湿、泻火解毒、止血安胎等功效［1］。黄芩素(baicalein，BAI)是其主要有效成分之一，化学结构属黄酮类，具有多种药理作用，如：抗菌、抗病毒、抗炎、抗变态反应、抗氧化、清除氧自由基、抗癌、抗肿瘤、抗凝、抗血栓形成和保护肝脏、心脑血管、神经元等作用［2］。目前临床主要用于抗炎和抗菌，但其抗流感病毒作用尚未见报道。本研究选择甲1型流感病毒FM1株，观察BAI的体内抗病毒作用，现报道如下。
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