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天花粉蛋白的构效关系及进入细胞的途径           
天花粉蛋白的构效关系及进入细胞的途径

【摘要】    天花粉蛋白(Trichosanthin, TCS)因具有妊娠引产、抗肿瘤、抗病毒及免疫调节等多种药
  [16]Shaw p C , lee KM ,wong KB. Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties[J].Toxicon,2005, 45(6):683.
  
  [17]Xia X.F., Wang F., Yang M., et al.Trichosanthin’s interfacial interactions with phospholipids: a monolayer study[J].Colloid Surf. B Biointerfaces, 2004,39 (3):105.

  [18]Lu Y., Xia X., Sui S, et al. The interaction of trichosanthin with supported phospholipid membranes studied by surface plasmon resonance. Biochem. Biophys[J]. Res. Commun, 2007,302 (1):89.

  [19]Zhang F., Lu Y.J., Shaw P.C., et al. Change in pH-dependent membrane insertion characteristics of trichosanthin caused by deletion of its last seven C-terminal amino acid residues[J]. Biochemistry ,2003,68 (4):436.

  [20]Chan W.Y., Huang H., Tam S.C.,et al. Receptor-mediated endocytosis of trichosanthin in choriocarcinoma cells[J]. Toxicology, 2003,186 (3):191.

  [21]Chan W.L., Shaw P.C., Tam S.C.,et al. Trichosanthin interacts with and enters cells via LDL receptor family members[J]. Biochem. Biophys. Res. Commun ,2000, 270 (2):453.

  [22]Christensen E.I., Birn H., Verroust P.,et al. Megalin-mediated endocytosis in renal proximal tubule[J]. Ren.Fai, 2004,20 (2):191.

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