炎症细胞因子与心力衰竭研究进展


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炎症细胞因子与心力衰竭研究进展

炎症细胞因子与心力衰竭研究进展

【关键词】 炎症;细胞因子;心力衰竭;心肌收缩力;心室重构

细胞因子是细胞受内、外环境变化刺激后分泌的一组功能性蛋白分子，其家族成员包括肿瘤坏死因子(TNF)、白细胞介素(IL)、干扰素、集落刺激因子、生长因子、趋化因子家族等。细胞因子主要参与激活信号转导通路、增加细胞内信使水平、激活转录因子、诱导编码基因等生理和病理过程。在众多炎症细胞因子中，起主要作用的是TNFα、IL1β、IL6、TGFβ、IL10。炎症细胞因子级联反应对于心衰的发生、
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