| 兔角膜碱烧伤后LYVE-1的表达及意义 |
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ly were killed at t=1 day, 3 day, 7 day and 14 day after operation respectively. The corneal expression of LYVE-1 was then examined through immunohistochemistry method. Result: LYVE-1 expression in the experimental group exhibits progressive increase starting from the third day after operation and reaches its peak presumably around the 7th day after operation. LYVE-1 expression in the experimental group exhibits much higher level than the control group at each time point (t=3 day, 7day and 14 day) examined. Conclusion: Corneal neolymphangiogenesis plays an important role in post-burn corneal restoration.
Key words Corneal alkali burn; Neolymphangiogenesis;LYVE-1
角膜碱烧伤是临床上复杂而难以治愈的眼病之一,碱性物质既溶于水又溶于脂肪，因而进入细胞后，能迅速与细胞结构中的脂类发生皂化反应，故极易渗入眼组织深层，破坏眼内组织。本实验建立兔角膜碱烧伤的模型,通过免疫组化测定淋巴管内皮透明质酸盐受体1（LYVE-1)的表达，为进一步证实角膜碱烧伤后角膜新生淋巴管的存在提供有力的证据。
1 材料与方法
1.1 动物及分组 选择内蒙古农业大学动物中心提供的3～4月龄健康新西兰大白兔24只，体重2～3kg，复合饲料喂养。将24只 上一页 [1] [2] [3] [4] [5] 下一页 |
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