作者:赖东兰,李宜瑞,陈晓刚,田慧,唐彦
【摘要】 【目的】观察益智宁煎剂对注意缺陷多动障碍(ADHD)模型动物——自发性高血压大鼠(SHR)的主动注意力的影响。【方法】选用SHR大鼠36只,随机分为益智宁高、低剂量组(剂量分别为1454、727g·kg-1·d-1)和空白对照组,采用“五项选择的连续反应时间任务”方法检测给药前后大鼠持续性主动注意力的变化。【结果】益智宁高、低剂量组大鼠持续性主动注意力显著提高,与给药前及空白对照组比较均有显著性差异(P<001),但两剂量组间比较无显著性差异(P>005)。【结论】益智宁煎剂可改善SHR大鼠的持续性主动注意力。
【关键词】 注意缺陷多动障碍/中药疗法;益智宁煎剂/药理学;疾病模型,动物;大鼠
Abstract: ObjectiveTo observe the active attention influence of Yizhining Decoction(YD) on the spontaneous hypertensive rats(SHR), which are used as the animal model of attention deficit hyperactivity disorder(ADHD). MethodsThirtysix SHR were equally randomized into highdose YD group (at a dose of 1454g·kg-1·d-1), lowdose YD group (at a dose of 727g·kg-1·d-1) and control group. The changes of sustained active attention in SHR were observed by the method of 5-choice serial response time task before and after treatment. ResultsThe sustained active attention in both highdose and lowdose YD groups were presented obviously in advance, and the difference was significant (P<001) compared with the control group, but the differencewas insignificant (P>005)between highdose and lowdose groups. ConclusionYizhining Decoction can improve the sustained active attention of SHR.
Key words:ATTENTION DEFICIT HYPERACTIVITY DISORDER/TCD therapy;YIZHINING DECOCTION/pharmacology;DISEASE MODELS,
注意缺陷多动障碍(attention deficit hyperactivity disorder, ADHD),又名儿童多动症,以注意缺陷、多动、冲动为主要表现,是常见的儿童行为精神障碍,患病率高,且常伴有学习障碍、品行障碍、抽动障碍及某些情绪障碍,严重危害儿童的身心健康,但目前现代医学尚缺乏治愈方法[1]。迄今已有不少中医药治疗ADHD取效的临床报道,但动物实验方面有待进一步研究。自发性高血压大鼠(SHR)作为遗传动物模型,是目前研究ADHD使用最为广泛的模型动物[2]。本实验采用“五项选择的连续反应时间任务”(5CSRTT)的方法[2],观察益智宁煎剂对ADHD模型动物——自发性高血压大鼠的持续性主动注意力的影响,现报道如下。
1材料与方法
11动物
SHR大鼠36只,雄性,周龄11周,体质量245~290g,购于四川省医学科学院实验动物研究所,合格证号:0018751。每只大鼠均生活在空间为41cm×25c [1] [2] [3] 下一页 |