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升血灵胶囊联合ALG/ATG和CSA治疗重型再生障碍性贫血疗效的临床观察           
升血灵胶囊联合ALG/ATG和CSA治疗重型再生障碍性贫血疗效的临床观察

                     作者:周郁鸿 郭宇 胡致平 沈一平 沈建平 俞庆宏

【摘要】  [目的]观察升血灵胶囊联合抗淋巴细胞球蛋白/抗胸腺细胞球蛋白和环胞菌素A治疗重型再生障碍性贫血的临床疗效。[方法]收集我院治疗的重型再生障碍性贫血60例,其中升血灵胶囊联合ALG/ATG和CSA治疗27例为治疗组,以ALG/ATG+CSA治疗33例为对照组,比较患者治疗前后血常规,骨髓象,造血干/祖细胞生长等指标。[结果]治疗组有效率77.8%,对照组有效率66.7%,两组疗效无明显差异(P>0.05)。治疗组在减轻临床症状,改善生活质量等方面优于对照组。[结论]升血灵胶囊能缩短ALG/ATG+CSA治疗重型再生障碍性贫血的反应时间,为治疗重型再生障碍性贫血的有效中成药。

【关键词】  升血灵胶囊;抗淋巴细胞球蛋白;抗胸腺细胞球蛋白;环胞菌素A;重型再生障碍性贫血

  Abstract:[Objective]To evaluate the effects of severe aplastic anemia treated with combination of Shengxueling and antilymphocyte globulin(ATG),cyclosporin A(CSA).[Methods]Sixty patients diagnosed severe aplastic anemia(SAA) were divided into two groups: treatment group(27 cases) treated with combination of Shengxueling and ATG,CSA,control group(33 cases) treated with ATG,CSA.To evaluate the effects of SAA treated with combination of Shengxueling and ATG,CSA by patients` blood routine test,bone marrow routine test,the situation of hematopoietic stem cell growth etc.between preand post treatment.[Results]The effective rate of the treatment group is 77.8%,66.7% for the control group,P>0.05,showing marked statistical difference.Observation group is better than the control group in alleviating the symptoms and improving quality of life and so on.[Conclusions]Shengxueling would be able to shorten the response time of SAA treated with ATG,CSA.Shengxueling is an effective Chinese medicine to treat SAA.

  Key words:Shengxueling capsule; antilymphocyte globulin;antithymus cell globulin;cyclosporin A; severe aplastic anemia
   
  再生障碍性贫血(aplastic anemia,AA)是一种获得性骨髓造血功能衰竭症,主要发病机制是T细胞免疫亢进介导的造血组织损伤,表现为骨髓造血功能低下,全血细胞减少和贫血、出血、感染证候群。重型再生障碍性贫血(severe aplastic anemia,SAA)是一组病程短、进展快、预后不良的疾病,自然病程3~6个月。SAA发病机制中免疫因素占重要地位,强化免疫抑制治疗(immunosuppressive therapy,IST)是对不宜行造血干细胞移植患者的主要治疗方案,ALG/ATG+CSA是SAA非移植治疗的

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