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作者：陈兴玲 周惠萌 胡毓秀 郑金英 刘英超 郑华君
【摘要】 ［目的］探讨非药物因素对幽门螺旋杆菌治疗的影响。［方法］对1515例幽门螺旋杆菌（HP）根治资料，以每年为一时段，按照不同年龄、性别、疗程分别统计，并对各组数据（采用SPSS13.0软件）进行分析。［结果］ 1515例，HP总体根治成功率73.5%。不同时段、性别HP根治成功率无显著差别（P值分别为0.091，0.446）。年龄小于35岁，HP根除成功率显著提高（P=0.001）。年龄、性别与HP根除率相关（Kendall相关系数分别为0.083,-0.051）,14d疗程HP根治率优于7d（P=0.001）。［结论］年龄、性别及疗程均与HP根治成功率有关。
【关键词】 幽门螺杆菌；根治；年龄
Abstract: ［Objective］ To explore the effects of nondrugs on H.pylori eradication by analyzing a longterm, a large number of clinical data.［Methods］Data of H.pylori eradication were collected from November 2000 to June 2008 and recorded according to different age，gender and treatment course(7 or 14 days).The data were analyzed with SPSS 13.0.［Results］ The total of 1,515 patients were assessed, of them,the total rate of H.pylori eradication was 73.5%.No significant statistical difference was observed when compared the rates among different period or gender (P=0.091, 0.446, respectively).Analysis of age determined that patients aged less than 35 years had significantly improved outcome compared with older patients (P=0.001).The eradication rate was correlated with age, gender (Kendall correlation coefficient is 0.083,0.051 respectively),and the course for 14 days was prior to 7 days (P=0.001).［Conclusions］The rate of H.pylori eradication was associated with age, gender and course.
Key words: Helicobacter Pylori; eradication; age
幽门螺旋杆菌（HP）感染是胃炎，胃、十二指肠溃疡，甚至胃癌的主要致病因子。本文收集自2000年11月以来本院根治HP的相关资料，从不同时段、年龄、性别、疗程等方面进行分析，以期为临床根治HP提供借鉴。
1 对象与方法
1.1 临床资料 收集2000年11月1日至2008年6月30日在我科行14C呼气试验患者1515例，男769例，女572例；年龄最大94岁，最小14岁。均经14C呼气试验或胃镜检查术中尿素酶试验，明确有HP感染，抗HP治疗方案确定，并于疗程结束后至少4周复查14C呼气试验的病例。复查结果阴性者为HP根治成功，结果为阳性者为HP根治失败。
1.2 数据整理 将数据按治疗时段、年龄段、性别、疗程进行分类。 [1] [2] [3] 下一页 |
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