| 初诊2型糖尿病患者两种胰岛素强化治疗临床观察 |
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【摘要】 目的 探讨短期胰岛素强化治疗对伴高血糖初发2型糖尿病患者的临床疗效及其对胰岛B细胞功能的影响。方法 对78例初诊2型糖尿病( T2DM)患者随机分为持续胰岛素皮下输注（CSII） 组和多次胰岛素皮下注射（MSII）组进行强化治疗2周，测定治疗前后空腹及馒头餐后2 h血糖及胰岛素，并计算胰岛素分泌指数(HOMAβ)和胰岛素抵抗指数(HOMAIR)，观察两组治疗达标时间，胰岛素用量及对胰岛B细胞功能的影响。结果 两组患者治疗期间FPG和2 h PG比较无显著差异，胰岛素用量和达标时间有统计学意义，低血糖发生率两组间有统计学意义，两组治疗后HOMAβ较治疗前增高，HOMA IR均较治疗前降低，差异具有显著性（P<0.05）。结论 短期CSII和MSII治疗均可改善新诊断2型糖尿病(T2DM)患者B细胞功能，减轻胰岛素抵抗，CSII 较MSII临床效果好，达标快，胰岛素用量少，低血糖发生率低。
【关键词】 2型糖尿病； 胰岛素强化治疗； 胰岛B细胞
【Abstract】 Objective To study the effects of shortterm intensive insulin treatment on the β cell function and clinical effects in newly diagnosed type 2 diabetic patients. Methods 78 newly diagnosed type 2 diabetic patients were randomly divided into two groups: continuous subcutaneous insulin infusion (CSⅡ) and multiple daily infusion (MSⅡ),and were treated by CSⅡ for 2 weeks. The levels of fasting plasma glucose( FPG),2 hours postprandial glucose(2hPG) were detected before and after the treatment. HOMAIR and HOMAβ were calculated. The initial time and the dosage of insulin, the functions of islet cells were observed. Results There were no significant differences in FPG and 2hPG in two groups. The initial time and the dosage of insulin, HOMAIR and HOMA had statistical significance(P<0.05). Conclusion The excellent glycemic control and improvement of betacell function can be induced by shortterm CSII intensive therapy in newly diagnosed type 2 diabetic patients.
【Key words】 type 2 diabetesmellitus; insulin; intensive treatment; pancreatic beta cells
本研究旨在探讨短期胰岛素强化治疗对伴高血糖初发2型糖尿病患者的临床疗效及其对胰岛B细胞功能的影响。比较持续胰岛素皮下输注（CSII）组和多次胰岛素皮下注射（MSII）组对血糖、胰岛素用量、达标时间、胰岛B细胞功能和低血糖发生频率的差异。为2型糖尿病患者早期胰岛素强化治疗寻找依据。
1 资料和方法
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