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加味小柴胡汤对顺铂诱导BRL细胞核转录因子和热休克蛋白70表达的影响 |
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| 加味小柴胡汤对顺铂诱导BRL细胞核转录因子和热休克蛋白70表达的影响 |
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nd decrease in HSP70 of BRL cell induced by cisplatin compared with control group. There was a significant decrease of NF-kB in modified Xiaochaihu decoction group compared with cisplatin group. There were increases of the expression of HSP70 in both high and low dose group, but only the high dose group demonstrated significant difference. Conclution The expression of NF-kB of BRL cell induced by cisplatin can be inhibited while the expression of HSP70 can be enhenced by modified Xiaochaihu decoction. It may be one of important mechanisms of relieving cell oxidize lesion and inhibiting apoptosis by modified Xiaochaihu decoction.
Key words：BRL cell；cisplatin；modified Xiaochaihu decoction；NF-kB；HSP70
核转录因子-kB(NF-kB)是一种能与免疫球蛋白k轻链基因的增强子kB序列特异结合的蛋白因子,具有多向转录调节作用,当细胞氧化损伤后NF-kB的表达增强[1]。热休克蛋白(HSP)是机体在各种应激性侵害时所产生的一种高度保守蛋白质, HSP70是HSP中最重要的一种中等分子量蛋白,其表达能够对应激状态下细胞产生保护作用。HSP的细胞保护作用可能是恢复和维持抗氧化酶功能,修复其在应激状态时被破坏的功能蛋白,从而稳定细胞结构,使细胞维持正常的生理功能[2]。笔者利 上一页 [1] [2] [3] [4] [5] [6] 下一页 |
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