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穴位埋线联合健脾祛痰中药对肥胖型多囊卵巢综合征胰岛素抵抗及脂肪细胞因子的影响 |
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| 穴位埋线联合健脾祛痰中药对肥胖型多囊卵巢综合征胰岛素抵抗及脂肪细胞因子的影响 |
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作者：陶莉莉，傅艳红，谢蓬蓬，吴彤，桑霞，龙泳伶，曾诚，张玉珍
【摘要】 【目的】观察穴位埋线联合健脾祛痰中药对肥胖型多囊卵巢综合征（ＰＣＯＳ）患者胰岛素抵抗及脂肪细胞因子的影响。【方法】采用随机数字表法将４２例肥胖型ＰCOS患者随机分为2组，针药组22例予穴位埋线联合加减苍附导痰汤治疗，中药组２０例予加减苍附导痰汤治疗。连续治疗３个月为１个疗程。观察２组治疗前后月经情况，检测治疗前后患者的体质量指数（ＢＭＩ）、空腹血糖（ＦＰＧ）、空腹胰岛素（ＦＩＮＳ）以及胰岛素敏感指数（ＩＳＩ）、瘦素（Leptin)、肿瘤坏死因子α(TNFα)、抵抗素（Resistin）等的变化，记录胰岛素抵抗（ＩＲ）者的例数。【结果】月经改善总有效率针药组为８１８％，中药组为６５０％，２组比较差异有显著性意义（Ｐ＜００５）。针药组妊娠者３例，中药组妊娠者１例。治疗后２组ＢＭＩ、ＦＩＮＳ、ＩＳＩ均明显改善，与治疗前比较，差异有显著性意义（Ｐ＜００５），其中针药组改善程度更为显著（与中药组比较，Ｐ＜００５）。治疗后２组Leptin、TNFα、Resistin均明显降低（与治疗前比较，Ｐ＜００５），其中针药组的Leptin、TNFα值下降更为显著（与中药组治疗后比较，Ｐ＜００５）。【结论】穴位埋线联合健脾祛痰中药治疗肥胖型ＰＣＯＳ患者疗效确切，其效果明显优于单用中药治疗。其作用机制可能与降低ＢＭＩ及脂肪细胞因子Leptin、TNFα、Resistin水平，从而改善ＩＲ有关。
【关键词】 多囊卵巢综合征／中药疗法；多囊卵巢综合征／穴位疗法；埋线；健脾祛痰
Abstract： Objective To observe the effect of acupoint catgutembedding (ACE) therapy combined with spleenstrengthening and phlegmremoving herbs on insulin resistance (IR) and adipocyte factors in patients with obesetype polycystic ovary syndrome (PCOS).Methods Fortytwo obesetype PCOS patients were randomized into two groups:group A (N=22) received ACE combined with modified Cang Fu Daotan Decoction,and group B (N=20) received modified Cang Fu Daotan Decoction alone.Three months constituted one treatment course.The change of menstruation was observed,and body mass index (BMI),fasting plasma glucose (FPG),fasting insulin (FINS) and insulin sensitivity index (ISI),leptin,tumor necrosis factor α(TNFα),and resistin were detected before and after treatment.Meanwhile,the number of patients with IR was also recorded.Results The improvement rate of menstruation was 818% in group A and 650% in group B (P＜005).There were 3 patients being pregnant in group A,and there was one in group B.After treatment,BMI,FINS and ISI were much improved in the two groups (P＜005),and the improvement was obvious in group A (P＜005);serum levels of leptin,TNFα and [1] [2] [3] [4] 下一页 |
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