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环孢素A、维拉帕米、川芎嗪对胃癌多药耐药细胞株SGC-7901/ADR逆转作用的研究 |
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| 环孢素A、维拉帕米、川芎嗪对胃癌多药耐药细胞株SGC-7901/ADR逆转作用的研究 |
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vity of SGC-7901/ADR cells to Fluorouracil (5-FU). CsA, VP, and TMP at non-toxic doses were separately applied together with 5-FU to examine potential reversal effect against SGC-7901/ADR cells by each agent. Results: SGC-7901/ADR cells are resistant to 5-FU with relative resistance (RF) of 97.49. The non-cytotoxic dose limits for CsA, VP, and TMP are 3.0 mg/L, 10.0 mg/L, and 300.0 mg/L respectively. Both VP and TMP but not CsA exert dose-dependent reversal effect against SGC-7901/ADR cells with TMP at 300.0 mg/L exerting stronger reversal effect comparing with VP at 10.0mg/L (P<0.01). At 300.0 mg/L, TMP reduces the RF of SGC-7901/ADR cells to the value of 12.89 and lowers the IC50 of 5-FU from 13.001 mg/L to 1.542 mg/L with a reversal fold of 8.43. Conclusion: Multi drug resistance cell line SGC-7901/ADR is resistant to 5-FU while TMP at 300.0 mg/l is the most effective reversal agent examined here against SGC-7901/ADR cells.
Key words Gastric Canc上一页 [1] [2] [3] [4] [5] [6] [7] [8] 下一页 |
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