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血浆同型半胱氨酸及其相关酶基因多态性与Alzheimer病的关系 |
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| 血浆同型半胱氨酸及其相关酶基因多态性与Alzheimer病的关系 |
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red by means of cyclophorase and the polymorphism of MTHFR C677T was analyzed by polymerase chain reaction-restrictive fragment length polymorphism （PCR-RFLP） in 68 patients with AD and 68 healthy controls.Results The plasma Hcy level of AD group （13.92±5.513） umol/L was significantly higher than that （10.83±3.800）μmol/L of control group. Generally the gene types of MTHFR C677T varied greatly between both groups. The frequency of C/T genetype was remarkably higher in AD group （64.71%） than that in the latter （42.65%）.Conclusion There must be some possible relationship between the elevated level of Hcy and the development of AD. Gene polymorphism led by gene mutation of MTHFR C677T is possibly involved in the inheritance mechanism of AD. The elevated Hcy level is due to inherited factor in Han people of Shanxi Province to some extent.
［Key words］ Alzheimer’s disease; homocysteine; methylene tetrahydrofolate reductase; gene mutation
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