老年糖尿病中医辨证与细胞免疫关系分析 |
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【摘要】 [目的]观察老年糖尿病不同中医证型间T淋巴细胞亚群的变化。[方法]将84例老年糖尿病患者分为阴虚热盛(20例)、气阴两虚(21例)、阴阳两虚(18例)、气阴两虚兼血瘀(25例)4组,另设20例健康志愿者为对照组,观察各组CD3、CD4、CD8、CD4/CD8及FPG、FIns、HOMAIR、HBCI等变化情况。[结果]不同中医证型中阴虚热盛型CD3、CD4、CD8、CD4/CD8与健康对照组相比其差异无统计学意义(P>0.05);而气阴两虚型、气阴两虚兼血瘀型、阴阳两虚型的CD3、CD4值分别与健康对照组、阴虚热盛型比较明显下降其差异均有统计学意义(P<0.05),且三组患者FIns、HOMAIR值较阴虚热盛型相比其差异有统计学意义(P<0.05);阴阳两虚型FPG、HOMAIR及HBCI与阴虚热盛型、气阴两虚型、气阴两虚兼血瘀型比较,其差异均有统计学意义(P<0.05),阴阳两虚型CD8值与其他四组相比明显升高,且CD4/CD8比值与健康对照组、阴虚热盛型比较其差异有统计学意义(P<0.05)。[结论]老年糖尿病患者不同中医证型组胰岛素抵抗程度不同,T淋巴细胞亚群变化亦有差异。胰岛素抵抗、B细胞功能及细胞免疫状态三者之间可能相互影响。
【关键词】 老年糖尿病;中医辨证;细胞免疫
Abstract:[Objective] To explore the changes of subgroup of Tlymphocyte in different TCM types of senile diabetes.[Method] Divide 84 cases into 4 groups: I,Yin deficiency excessive heat(20);II,deficiency of both Qi and Yin(21);III,deficiency of both Yin and Yang(18);IV,deficiency of both Qi and Yin combined with blood stasis(25),set up other healthy 20 cases for control group (V);observe the states of CD3,CD4,CD8,CD4/CD8,FPG,Fins,HOMAIR and HBCI in each group.[Result] There’s no statistical difference between Yin deficiency excessive heat group and control group on CD3,CD4,CD8,CD4/CD8(P>0.05);there’s statistical difference between II,IV,III and V,I on CD3 and CD4(P<0.05)by markedly being reduced,so were Fins and HOMAIR compared with I,also FPG,HOMAIR and HBCI compared between III and I,II,IV;while CD8 in III was much more increased than other 4 groups,and CD4/CD8 had statistical difference between it and V and I(P<0.05).[Conclusion] Senile diabetes in different TCM types has different insulin resistance and subgroup of Tlymphocyte.Insulin resistance,B cell function and cell immune may influence each other.
Key words: senile diabetes;TCM differentiation;cell immune 为客观评价老年糖尿病患者的免疫状态,观察不同中医证型患者的免疫特点,我们就临床常见几种证型的相关细胞免疫实验室参数进行了初步研究,旨在帮助临床制定治疗策略、判断预后及发挥中医中药的整体调节优势。
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