| 褪黑素对大鼠脊髓损伤后iNOS表达的影响 |
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ithout melatonin treatment, rats were killed at different time (8h, 24h, 72h, 7d, 14d). And rats of sham injury group were killed at 14d post SCI operation. HE staining and Immunohistochemistry method were employed to detect iNOS expression in spinal cord. Results:Melatonin treatment significantly reduces the induction of iNOS expression in spinal cord of rats subjected to SCI operation(P<0.05 or 0.01). Conclusion:The result suggests that melatonin may exert protective effect on spinal cord injury through inhibiting the induction of iNOS expression.
Key words Spinal cord injury; Melatonin; Inducible nitric oxide synthase (iNOS)
脊髓损伤 (spinal cord injury, SCI)后的继发性损伤是一个复杂的病理过程, 包括兴奋性氨基酸、氧化性代谢产物和致炎细胞因子等多种效应因子的释放，可导致脊髓组织不可逆损害，表现为不同程度的运动、感觉和自主神经功能障碍。一氧化氮 (NO)作为在体内广泛存在并具有多重生物学效应的信号介质可能起很重要的作用，体内NO由一氧化氮合酶 (nitric oxide synthase, NOS)生成,NOS广泛存在于包括中枢神经系统在内的各系统中。NOS有3种亚型,其中诱生型一氧化氮合酶(inducible nitric oxide synthase, iNOS)产生的 NO量大、持续时间长,通过直接引起过氧化损伤或作为 上一页 [1] [2] [3] [4] [5] [6] [7] [8] 下一页 |
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