利用体外培养的人近端肾小管上皮细胞, 研究PTH对其转分化以及转化生长因子β1(TGFβ1)表达的影响, 以探讨PTH在RIF发病机制中的作用。
1 材料和方法
1.1 材料 人近端肾小管上皮细胞(HK2细胞株)购自 [2] Lan HY. Tubular epithelialmyofibroblast transdifferentiation mechanisms in proximal tubule cells[J]. Curr Opin Nephrol Hypertens, 2003, 12(1): 25-29.
[3] Li JH, Wang W, Huang XR, et al. Advanced glycation end products induce tubular epithelialmyofibroblast transition through the RAGEERK1/2 MAP kinase signaling pathway[J]. Am J Pathol, 2004, 164(4): 1389-1397.
[4] Taki K, Nakamura S, Miglinas M, et al. Accumulation of indoxyl sulfate in OAT1/3positive tubular cells in kidneys of patients with chronic renal failure[J]. J Ren Nutr, 2006, 16(3): 199-203.
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[6] Isakova T, Gutierrez O, Shah A, et 上一页 [1] [2] [3] 下一页 |