TWEAK诱导类风湿关节炎成纤维样滑膜细胞合成MMP3的实验研究


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TWEAK诱导类风湿关节炎成纤维样滑膜细胞合成MMP3的实验研究

TWEAK诱导类风湿关节炎成纤维样滑膜细胞合成MMP3的实验研究

p; RA FLS were primarily cultured and stimulated with TWEAK. ELISA was used to detect the concentration of MMP3 in cellcultured fluid. The gene mRNA expression of MMP3 was measured by RTPCR. RESULTS: The level of MMP3 induced by TWEAK at 50 and 100 μg/L was higher than that in control group, which had significant statistic difference（P<0.05）.The expression level of MMP3mRNA induced by TWEAK at 100 μg/L was 1.26 times higher than that in the control group, which had significant statistic difference（P<0.05）.TNFα and IL1β had synergetic effect on the synthesis and mRNA expression of MMP3. The level in the synergetic group was significantly higher than that in the simple TWEAK group , which had significant statistic difference（P<0.05）. CONCLUSION: TWEAK can induce RA FLS to synthesize MMP3 and damage the articular bone and cartilage directly. TNFα, IL1β and TWEAK had synergetic effects during the synthesis of MMP3 in RA FLS.

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