¡¡¡¡£ÛAbstract£Ý  AIM:   To explore the therapic effect of T¦Á146ª²162ª² iMDCs in C57BL/6 mice with experimental autoimmune myasthenia graves(EAMG),  and illustrate whether this therapic effect is related with the change of B cells activation. METHODS:   Adult male C57BL/6 mice were randomly divided into EAMG groups(A),  the prevention group(B) and control group(C);  Immature bone marrow dendritic cells were cultured and pulsed with T¦Á146ª²162.  Mice of A group and B group were evaluated for clinical score till the day they were put to death. The expression and phosphorylation of Syk,  Lyn,  Btk and PLCª²¦Ã2 protein were measured by Western blot. RESULTS:   75% mice of A group and 25% mice of B group were developed the accumulated incidence,  the difference was significant (P<0.05). The average clinical score of A group and B group were 1.69¡À1.12 vs 0.35¡À0.67(P<0.01) at the termination of experiment. The expression

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