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免疫干预实验性自身免疫性重症肌无力小鼠的B细胞活化机制 |
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| 免疫干预实验性自身免疫性重症肌无力小鼠的B细胞活化机制 |
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and phosphorylation of Syk and PLCγ2 protein in spleen and lymphonode of the mice of A group were higher than those of C group (P<0.01) and B group (P<0.05). Compared with C group, those of B group were higher (P<0.05); The expression and phosphorylation of Lyn protein in spleen and lymphonode of the mice of A (P<0.01) and B (P<0.05) groups were lower than those of C group. Compared with A group, those of B group were higher (P<0.05); The expression of Btk protein in spleen and lymphonode of the mice of A (P<0.01) and B (P<0.05) groups were higher than those of C group. And those of B groups were lower than those of A group (P<0.05). But there were no remarkable differences among the phosphorylation of Btk protein of three groups. CONCLUSION: Tα146162iMDCs can prevent EAMG and probably ameliorate EAMG by the negative regulation on BCR signaling.
［Keywords］experimental eutoimmune myasthenia graves; Tα1461 上一页 [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] ... 下一页 >> |
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